Brief overview

buy chm-SGT-151 online at TLC which is chemically known as 5F-CUMYL-PEGACLONE is a gamma carboline based synthetic cannabinoid that is being sold as a designer drug. It was first identified in 2017 in Germany.  It acts as a potent full agonist of the CB1 receptor. It appears to be more toxic than related compounds such as  and has been linked to numerous serious adverse reactions, some fatal.

Experimentation with chm-sgt-151

To detect identical metabolites with the non-fluorinated analog CUMYL-PEGACLONE, a set of six urine samples only positive for metabolites of CUMYL-PEGACLONE was analyzed by the LC–MS/MS method described above. Additionally, the metabolite ranking was compared to the data of the human metabolism study of CUMYL-PEGACLONE . Within this comparative analysis, six identical metabolites (M01, M02, M04, M06, M08, M10) were detected. An overlayed chromatogram is shown in the Supplementary Materia. buy chm-SGT-151 online

buy chm-sgt-151 online

In the present study, the human phase I metabolism of the recently emerged γ-carbolinone derived SC 5F-CUMYL-PEGACLONE was investigated in a collective of human urine specimens. As it has been shown for the non-fluorinated analog CUMYL-PEGACLONE, the drug is subject to extensive metabolism in humans. Metabolic modifications mainly occurred at the γ-carbolinone core and the 5-fluoropentyl chain. The main in vivo metabolite M06 is an interesting marker for urine analysis when maximum sensitivity is needed (e.g., drug abstinence testing), but this metabolite can also arise from consumption of the non-fluorinated analog CUMYL-PEGACLONE and buy chm-SGT-151 online.   Legal cannabinoids drug profile.

Conclusion notes

 In total, 15 different phase I metabolites were detected in the investigated set of urine samples. The metabolic reactions in vivo included hydroxylation, formation of a dihydrodiol, hydrolytic defluorination, N-dealkylation, oxidation to the pentanoic acid metabolite, side chain degradation to the propionic acid metabolite and combinations thereof. buy chm-SGT-151 online. The metabolites were named serially numbered in the order of their retention times (RTs). The parent compound was not detected in any of the urine samples. Since the identification of the particular position of functional groups introduced by metabolic reactions would require isolation of metabolites for structure elucidation, e.g., by nuclear magnetic resonance (NMR) spectroscopy or synthesis of reference material, the exact chemical structures of some metabolites remain unclear.

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