Research Chemicals and Stimulants

What are research Chemicals?

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  In their legitimate scientific form, research chemicals are just that—new chemicals in the research stage of development, so they come with hypotheses about their potential uses but little in terms of controlled studies and probable health risks. Chemical formulas are obtained by copying publicly published research; the structure is replicated and then mass-produced and sold, typically at

Research Chemical Laws

Research chemicals are commonly classified as synthetic drugs for legal and regulatory purposes. Synthetics are a broad grouping of drugs which include MDMA (ecstasy), ketamine, synthetic cathinones (bath salts), and synthetic cannabinoids (Spice and K2). Many agencies refer to these drugs as new psychoactive substances (NPS), as they are all manufactured in laboratory settings, and many of them have legal analogues that were developed specifically to bypass drug enforcement laws.1 Often, the packaging for these products has the warning label: not for human consumption.

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Types of Research Chemicals

  • 25I-NBOMe and 25C-NBOMe: These designer hallucinogens are taken orally and sometimes confused with LSD. Severe toxicity and deaths have been reported in connection with these substances.
  • 2C Series: A popular group of synthetic hallucinogens, these drugs contain 2,5-dimethyoxyphenethylamine. One of the more famous is 2C-E, also known as Europa. The drugs allegedly produce the same effects as LSD. Dangerous and unpredictable side effects include difficulty breathing and persistent, psychotic hallucinations. 
  • Acetyl fentanyl: With fentanyl, a potent prescription narcotic around 100 times more potent than heroin, already devastating the country, the introduction of acetyl fentanyl as a research chemical puts people struggling with opioid addiction at significant risk of death. This opioid product has been  out  but as a research chemical, human reactions to the substance have not been exhaustively documented.9
  • Arylcyclohexylamine: This group of chemicals is marketed as being similar to ketamine; they allegedly elicit dissociative, anesthetic, and hallucinogenic effects. While pharmaceutical ketamine is an arylcyclohexylamine, the group contains other, less understood research chemicals.
  • Bromo-DragonFLY: There is case report evidence to suggest that this synthetic psychedelic amphetamine derivative has led to severe toxic reactions.
  • Etizolam:  This is a long-acting prescription anti-anxiety medication. While etizolam is legal in India, Italy, and Japan to treat insomnia, it is not prescribed in the United States. People who struggle with benzodiazepine addiction have been known to purchase this drug through online retailers when it is marketed as a research chemical; unfortunately, the status of research chemical means that this version of etizolam has likely been tampered with, making it more dangerous. Use of the drug can lead to slurred speech, confusion, headaches, and drowsiness, among other side effects.
  • Methoxamine (MXE): This drug is a dissociative and pain suppressant, similar to ketamine; in fact, it is often sold as a ketamine derivative. MXE boasts effects like those of PCP, another dangerous synthetic psychoactive drug. The high from MXE lasts 5-7 hours. There are overdose deaths linked to this compound.
  • Methylhexanamine (DMAA): This designer stimulant is marketed as a synthetic cathinone replacement, especially after horrific reports around the dangers of bath salts. DMAA is sometimes found in the dietary supplement market for weight loss because supplements are poorly regulated in the US.
  • Other phenethylamines: Technically,  phenethylamines can be found in the body; most mammals produce these neurotransmitters, which are associated with infatuation and romance. They are stimulants, with effects like those of MDMA or amphetamines. When mixed in research chemicals, these drugs can lead to intense highs like those associated with crystal meth or ecstasy.15
  • Piperazines: More commonly found in industrial chemicals, these drugs are both stimulants and hallucinogens, believed to have amphetamine-like or MDMA-like psychoactive effects. Chemicals commonly found in this group include BZP, TFMPP, mCPP, and MeOPP. They are found as tablets, which could lead to confusion with other drugs in tablet form.
  • Tryptamines: These occur naturally in some plant species, although the intoxicating version is produced in a lab. These are hallucinogens that distort reality more than other forms of hallucinogenic substances. They can be found in tablet, powder, or blotter paper form, and there are dozens of chemicals widely available from this group

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